Welltok adds four new digital programs, Atrium Health adopts Butterfly's handheld ultrasound and more digital health deals

Also: Intel, UPenn and others employ AI for brain tumor identification; DrChrono integrates EHRsynergy's documentation tool.
Source: mobihealthnews - Category: Information Technology Source Type: news

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The ultrasound based non-invasive ICP measurement method has been recently validated. Correlation of symptoms and signs of intracranial hypertension with actual ICP measurements in patients with large intracra...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
(University of Virginia Health System) Focused sound waves create tiny bubbles inside cancer cells, causing them to die.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionOur results suggest that SDT with FL and low-intensity FUS is effective in inhibiting the growth of ectopic malignant gliomas in rats. The selective FL extravasation and accumulation in the tumor areas where the blood –brain barrier is damaged suggests the tumor-specificity of the treatment. The possibility to use this treatment in intracranial models and in human gliomas will have to be explored in further studies.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Multimodality 3D optical/CT and PET are valid translational methods to confirm drug delivery through a permeabilized BBB that can be used to enhance drug development in a preclinical setting. Furthermore, PET scanning using radiolabeled therapeutics has the potential to be translated to humans, as HIFU-mediated BBB permeability has entered early stage clinical trials. Support: NIH/NCI 5P01CA207206. The PET early drug development program is supported by the Columbia Dept. of Radiology and Irving Institute CTSA Translational Therapeutics Accelerator (UL1TR001873).
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Nonradioactive Probes (Poster Session) Source Type: research
(University of Virginia Health System) Focused ultrasound, the researchers hope, could revolutionize treatment for conditions from Alzheimer's to epilepsy to brain tumors -- and even help repair the devastating damage caused by stroke.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractObjectiveGlioblastoma is the most common primary brain tumor; survival is typically 12 –18 months after diagnosis. We sought to study the effects of sonodynamic therapy (SDT) using 5-Aminolevulinic acid hydrochloride (5-ALA) and high frequency focused ultrasound (FUS) on 2 glioblastoma cell lines.ProcedureRat C6 and human U87 glioblastoma cells were studied under the following conditions: 1  mM 5-ALA (5-ALA); focused ultrasound (FUS); 5-ALA and focused ultrasound (SDT); control. Studied responses included cell viability using an MTT assay, microscopic changes using phase contract microscopy, apoptot...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
ederico D’Agata Magnetic Oxygen-Loaded Nanobubbles (MOLNBs), manufactured by adding Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on the surface of polymeric nanobubbles, are investigated as theranostic carriers for delivering oxygen and chemotherapy to brain tumors. Physicochemical and cyto-toxicological properties and in vitro internalization by human brain microvascular endothelial cells as well as the motion of MOLNBs in a static magnetic field were investigated. MOLNBs are safe oxygen-loaded vectors able to overcome the brain membranes and drivable through the Central Nervous System (CNS) to deliver th...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
In brain tumor surgery, the quality and safety of the procedure can be impacted by intra-operative tissue deformation, called brain shift. Brain shift can move the surgical targets and other vital structures such as blood vessels, thus invalidating the pre-surgical plan. Intra-operative ultrasound (iUS) is a convenient and cost-effective imaging tool to track brain shift and tumor resection. Accurate image registration techniques that update pre-surgical MRI based on iUS are crucial but challenging. The MICCAI Challenge 2018 for Correction of Brain shift with Intra-Operative UltraSound (CuRIOUS2018) provided a public platf...
Source: IEE Transactions on Medical Imaging - Category: Biomedical Engineering Source Type: research
ConclusionsUltrasound BBB opening has just recently entered clinical trials with encouraging results, and the association of this strategy with immune therapeutics creates a new field of brain tumor treatment.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
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