Effects of oxidative stress on liver, brain and spinal cord of rats using L-NAME and treated with hydroxyurea. A model of sickle cell complication.

CONCLUSIONS: Following the use of L-NAME, hepatic tissue increased the number of Kupffer cells as oxidative stress and inflammatory response increased. The use of L-NAME caused an increase in lipid peroxidation products and, consequently, in oxidative stress in animals. Hydroxyurea doses of 35 mg / kg / day reduced TBARS values in liver, brain and spinal cord.
PMID: 32401830 [PubMed - as supplied by publisher]

Source: Acta Cirurgica Brasileira - May 14, 2020 Category: Surgery Authors: Santos Neto ATD, Silva IS, Ivo ML, Rodrigues CT, Parisotto EB, Ramalho RT, Monteiro GM Tags: Acta Cir Bras Source Type: research