Type IV secretion of Helicobacter pylori CagA into oral epithelial cells is prevented by the absence of CEACAM receptor expression

ConclusionsThese results show that lack of CEACAM receptors on the surface of the oral epithelial cells was responsible for resistance toH. pylori CagA-dependent pathogenic activities, and confirms the important role for the T4SS-dependent interaction of these receptors withH. pylori in the gastric epithelium.
Source: Gut Pathogens - Category: Microbiology Source Type: research