Evaluation of the effects of Maytenus ilicifolia on the activities of cytochrome P450 3A and P-glycoprotein.

CONCLUSION: The results suggest that M. ilicifolia can inhibit the intestinal metabolism and transport of drugs mediated by CYP3A and P-gp, respectively, however, involvement of other transporters and the clinical relevance of such interaction still need to be clarified.
PMID: 32394829 [PubMed - as supplied by publisher]

Source: Current Drug Metabolism - May 11, 2020 Category: Drugs & Pharmacology Authors: de Castro WV, do Nascimento SB, de Lima Nascimento M, de Araújo LL, de Oliveira FM, do Carmo Vieira M, Duarte-Almeida JM, Siqueira JM, da Costa César I, Derendorf H Tags: Curr Drug Metab Source Type: research