The Effect of Extracellular Calcium Metabolism on Aldosterone Biosynthesis in Physiological and Pathological Status
Horm Metab Res DOI: 10.1055/a-1157-0511Primary aldosteronism (PA) was reported to frequently harbor not only
cardiovascular diseases but also some metabolic disorders including
secondary calcium metabolic diseases. Recently, the potential association
between aldosterone producing cells and systemic calcium metabolism has been
proposed. For instance, PA is frequently associated with hypercalciuria or
hypocalcemia, which subsequently stimulates parathyroid hormone (PTH)
secretion. This altered calcium metabolism in PA patients could frequently
result in secondary osteoporosis and fracture in some patients. On the other
hand, extracellular calcium itself directly acts on adrenal cortex and has
been also proposed as an independent regulator of aldosterone biosynthesis
in human adrenals. However, it is also true that both PTH and vitamin D
pathways stimulate endocrine functions of adrenal cortical adenomas to
co-secret both aldosterone and cortisol. Therefore, it has become pivotal to
explore the potential crosstalk between aldosterone and systemic calcium
metabolism. We herein reviewed recent advances in these fields. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Gao, Xin Yamazaki, Yuto Tezuka, Yuta Omata, Kei Ono, Yoshikiyo Morimoto, Ryo Nakamura, Yasuhiro Satoh, Fumitoshi Sasano, Hironobu Tags: Review Source Type: research
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