The Impact of Glucocorticoid Co-Secretion in Primary Aldosteronism on Thyroid Autoantibody Titers During the Course of Disease
Horm Metab Res DOI: 10.1055/a-1164-1944Excess aldosterone is associated with the increased risk of
cardio-/cerebrovascular events as well as metabolic comorbidities
not only due to its hypertensive effect but also due to its proinflammatory
action. Autonomous cortisol secretion (ACS) in the setting of primary
aldosteronism (PA) is known to worsen cardiovascular outcome and potentially
exhibit immunosuppressive effects. The aim of this study was to determine
the impact of ACS status in patients with PA on kinetics of thyroid
autoantibodies (anti-TPO, anti-TG) pre and post therapy initiation.
Ninety-seven PA patients (43 unilateral, 54 with bilateral PA) from the
database of the German Conn’s Registry were included. Anti-TPO and
anti-TG levels were measured pre and 6–12 months post therapeutic
intervention. Patients were assessed for ACS according to their 24- hour
urinary cortisol excretion, late night salivary cortisol and low-dose
dexamethasone suppression test. Abnormal test results in line with ACS were
identified in 74.2% of patients with PA. Following adrenalectomy,
significant increases in anti-TPO levels were observed in patients with at
least one abnormal test (p = 0.049), adrenalectomized patients with
at least two pathological ACS tests (p = 0.015) and adrenalec...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Handgriff, Laura Adolf, Christian Heinrich, Daniel A. Braun, Leah Nirschl, Nina Sturm, Lisa Ladurner, Roland Ricke, Jens Seidensticker, Max Bidlingmaier, Martin Reincke, Martin Tags: Endocrine Research Source Type: research
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