The Remission Rate of Type 2 Diabetes Outpatients with Premixed Insulin: The Result of a 5-Year Prospective Study
Horm Metab Res 2020; 52: 316-321 DOI: 10.1055/a-1128-6957The aim of the study was to evaluate the remission rate with short-term
premixed insulin therapy in newly diagnosed type 2 diabetes outpatients and
investigate predictors contributing to the remission rate. A 5-year
prospective study was conducted with a total of 170 patients enrolled.
Patients were treated with premixed insulin monotherapy or insulin in
combination with one or two oral drugs. After glucose levels were well
controlled, insulin and oral drugs were discontinued in a stepwise manner.
The prolonged and partial remission rates were calculated and the possible
factors contributing to remission were also analyzed. A total of 164
subjects completed the research study. The prolonged remission, partial
remission and non-remission rates at the 5-year follow-up were 9.8, 59.8,
and 30.5%, respectively. The remission rate was negatively
correlated with disease duration (r=0.39). The combined rate of
remission (prolonged and partial remission) significantly decreased when the
duration was longer than 16 days, and reduced to approximately 50%
after 1 month. Moreover, 75% of prolonged remission patients had
duration of < 16 days. At the 5-year follow-up, the
prolonged remission rate was 9.8% and the partial remissi...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Liu, Fu-peng Sun, Ming-hui Zhao, Jun-yu Yang, Ming Zhou, Xiao-jun Zhang, Zhong-wen Dong, Jian-jun Liao, Lin Tags: Endocrine Care Source Type: research