GSE133317 TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7 –9

Contributors : Leonhard X Heinz ; JangEun Lee ; Felix Kartnig ; Konstantinos Papakostas ; Vitaly Sedlyarov ; Adrian C ésar-Razquin ; Patrick Essletzbichler ; Ulrich Goldmann ; Adrijana Stefanovic ; Johannes W Bigenzahn ; Stefania Scorzoni ; Peter Májek ; André C Müller ; F J King ; Jun Li ; Enrico Girardi ; M L Mbow ; Utkarsh Kapoor ; Patrick Essletzbichler ; Mattia D Pizzagalli ; Ariel Bensimon ; Jun Li ; Charles E Whitehurst ; Manuele Rebsamen ; Giulio Superti-FurgaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensToll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses. Here we show that a previously uncharacterized protein encoded by CXorf21 —a gene that is associated with systemic lupus erythematosus—interacts with the endolysosomal transporter SLC15A4, an essential but poorly understood component of the endolysosomal TLR machinery also linked to autoimmune disease. Loss of this type-I-interferon-inducible protein, which we refer t o as ‘TLR adaptor interacting with SLC15A4 on the lysosome’ (TASL), abrogated responses to endolysosomal TLR agonists in both primary and transformed human immune cells. Deletion of SLC15A4 or TASL specifically impaired the activation of the IRF pathway without affecting NF-κB and MAPK signalli ng, which indicates that ligand recognition and TLR engagement in the endolysosome occurred normally. Extensive mutagenesis of ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research