Protective actions of exercise ‐related FNDC5/Irisin in memory and Alzheimer's disease

AbstractThe proportion of elderly populations is rapidly booming, and human lifespan has considerably increased in the past century due to scientific and medical advances. However, the winds of change brought by the 21st century made sedentarism one of the factors that renders the brain vulnerable to age ‐related chronic diseases, such as Alzheimer's disease (AD). Conversely, physical exercise has been shown to stimulate molecular mechanisms beneficial to cognition. Here, we review evidence showing the positive effects of physical exercise in the brain. We further discuss recent evidence that iris in, a myokine stimulated by physical exercise derived from fibronectin type III domain‐containing protein 5 (FNDC5) transmembrane protein, has neuroprotective actions in the brain. Lastly, we highlight the importance of the crosstalk between the periphery and the brain in cognition and the therape utic potential of FNDC5/irisin in AD.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: REVIEW Source Type: research