Novel Approach for the Synthesis of Pyrrolo[2,1-c][1,4]Benzoxazines and Pyrrolo[1,2-a]Quinoxalines.

Novel Approach for the Synthesis of Pyrrolo[2,1-c][1,4]Benzoxazines and Pyrrolo[1,2-a]Quinoxalines.
Comb Chem High Throughput Screen. 2013 Dec 27;
Authors: Sanaeishoar T, Adibi-Sedeh S, Karimian S
Abstract
An efficient synthesis of alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[2,1-c][1,4]benzoxazine-3-carboxylates and alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[1,2-a]quinoxaline-3-carboxylates is described. This involves a three-component reaction between o-aminophenols or o-phenylenediamine, acetylenic esters and β-nitrostyrene derivatives using p-toluene sulfonic acid as a catalyst.
PMID: 24369957 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - December 27, 2013 Category: Chemistry Authors: Sanaeishoar T, Adibi-Sedeh S, Karimian S Tags: Comb Chem High Throughput Screen Source Type: research