Association of Surgical Hospitalization with Brain Amyloid Deposition The Atherosclerosis Risk in Communities –Positron Emission Tomography (ARIC–PET) Study

Conclusions The results do not support an association between surgical hospitalization and elevated brain amyloid.Editor ’s PerspectiveWhat We Already Know about This TopicHospitalization for medical illness and surgical procedures has been associated with subsequent cognitive decline in some older patientsAnimal models have suggested that surgery and anesthesia may lead to an increased production and accumulation of brain amyloidWhat This Article Tells Us That Is NewThis study found no differences in brain amyloid levels measured by positron emission tomography scans more than a decade after hospitalization for a surgical procedure when compared with patients who were not hospitalized and did not have a surgical procedureWhen low-risk surgical procedures were removed from the analysis, there was a small but statistically significant increase in brain amyloid in patients who had high-risk surgical procedures when compared with all patients who did not have a surgical procedureOn secondary analysis, patients with two or more surgical hospitalizations had a higher odds of elevated brain amyloid during late life when compared with participants with no surgical hospitalizations regardless of whether they had been hospitalized for medical reasonsThese data suggest that high-risk surgical procedures and multiple surgical procedures may be associated with increases in brain amyloid
Source: Anesthesiology - Category: Anesthesiology Source Type: research