Olanzapine for the Prevention of Postdischarge Nausea and Vomiting after Ambulatory Surgery A Randomized Controlled Trial

Conclusions When combined with ondansetron and dexamethasone, the addition of olanzapine relative to placebo decreased the risk of nausea and/or vomiting in the 24 hafter discharge from ambulatory surgery by about 60% with a slight increase in reported sedation.Editor ’s PerspectiveWhat We Already Know about This TopicNausea and vomiting after discharge from ambulatory surgery remains common despite use of current antiemetics.What This Article Tells Us That Is NewThe authors randomized women having day surgery to olanzapine 10  mg or placebo. All were also given both dexamethasone and ondansetron.Olanzapine reduced nausea and vomiting in the 24  h after hospital discharge from 38% to 14%, corresponding to a number-needed-to-treat of just four patients.
Source: Anesthesiology - Category: Anesthesiology Source Type: research