Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER) A Multicenter Matched Cohort Analysis

Conclusions Among a generalizable cohort of adult patients undergoing inpatient surgery at U.S. hospitals, the use of sugammadex was associated with a clinically and statistically significant lower incidence of major pulmonary complications.Editor ’s PerspectiveWhat We Already Know about This TopicApproximately 5% of patients experience a major pulmonary complication after noncardiac surgeryInadequate reversal of neuromuscular blockade increases the risk of pulmonary complicationsIn the United States, sugammadex is used with similar frequency as neostigmine at many hospitalsSugammadex provides more rapid and effective restoration of neuromuscular tone without systemic anticholinergic activity; however, neostigmine currently remains the mainstay of practiceWhat This Article Tells Us That Is NewIn a multicenter observational matched cohort study of noncardiac surgery, sugammadex administration was associated with a 30% reduced risk of pulmonary complications, a 47% reduced risk of pneumonia, and a 55% reduced risk of respiratory failure compared to neostigmine
Source: Anesthesiology - Category: Anesthesiology Source Type: research