Viruses, Vol. 12, Pages 533: Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection

Viruses, Vol. 12, Pages 533: Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection Viruses doi: 10.3390/v12050533 Authors: Tatsuo Kanda Reina Sasaki Ryota Masuzaki Naoki Matsumoto Masahiro Ogawa Mitsuhiko Moriyama Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research