GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in pre-hypertensive rats.

GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in pre-hypertensive rats. Am J Physiol Renal Physiol. 2020 May 11;: Authors: Jensen EP, Møller S, Hviid AVR, Veedfald S, Holst JJ, Pedersen J, Ørskov C, Sorensen CM Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone known to stimulate postprandial insulin release. However, GLP-1 also exerts extra-pancreatic effects including renal effects. Some of these renal effects are attenuated in hypertensive rats, where renal expression of GLP-1 receptors is reduced. Here, we assessed expression and vascular function of GLP-1 receptors in kidneys from young pre-hypertensive rats. We also examined GLP-1-induced vasodilation in the renal vasculature in wild-type (WT) and GLP-1 receptor knock-out (KO) mice using wire- and pressure-myography and the isolated perfused juxtamedullary nephron preparation. We investigated whether GLP-1 and the metabolite, GLP-1(9-36)amide, had renal vascular effects independent of the known GLP-1 receptor. We hypothesized that hypertension decreased expression of renal GLP-1 receptors. We also hypothesized that GLP-1-induced renal vasodilatation depended on expression of the known GLP-1 receptor. In contrast to normotensive rats, no immunohistochemical staining or vasodilatory function of GLP-1 receptors was found in kidneys from pre-hypertensive rats. In WT mice, GLP-1 induced renal vasodilation and r...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research