ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia

In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) are associated with a dismal outcome. Although uncoordinated 51-like kinase 1 (ULK1), whic...

Source: Journal of Experimental and Clinical Cancer Research - May 11, 2020 Category: Cancer & Oncology Authors: Doh Yu Hwang, Ju-In Eom, Ji Eun Jang, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong and Yoo Hong Min Tags: Research Source Type: research