Eosinophilic Granulomatosis with Polyangiitis Successfully Treated with Benralizumab.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare but potentially life-threatening antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis which affects, to varying degrees, the lungs, paranasal sinuses, heart, kidneys, skin and peripheral nervous system. It is strongly associated with asthma. Peripheral eosinophilia is a defining feature of EGPA and eosinophilic inflammation is often observed in biopsies of affected tissues. The pathogenesis of EGPA is not completely clear; the disease is probably the result of complex interactions in which genetic and environmental factors lead to an inflammatory response whose main actors are eosinophils and T and B lymphocytes.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research