Bone regenerative medicine: metatarsus defects in sheep to evaluate new therapeutic strategies for human long bone defect. A systematic review

Large bone defects occur due to trauma, bone tumor resection, infections and metabolic, degenerative or congenital diseases 1. The larger the defect, the more difficult to treat it because the damage to repair exceeds the intrinsic capacity of regeneration, leading to non-union complications2. Nearly 2 million/year of bone grafts (autografts, allografts or xenografts) are performed worldwide3 and among them, autograft is the gold standard due to its osteoinductivity, osteogenicity and osteoconductivity1,4.
Source: Injury - Category: Orthopaedics Authors: Source Type: research

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Authors: Sunwoo JY, Murrell GAC Abstract Managing massive irreparable rotator cuff tears is a challenge. Interposition graft repairs to bridge the torn defect are a promising solution. Many graft materials are available for interposition repairs including the following: allografts, autografts, extracellular matrix, and synthetic grafts. Currently, it is unknown how these materials compare biomechanically or in their clinical outcomes when used for interposition graft repairs of massive irreparable rotator cuff tears. Most allografts and autografts are similar, in maximal load and stiffness, to intact rotator cuff t...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
This article describes cases of bone augmentation with a combination of PRP + β -TCP and PRF + β -TCP for treatment of the chronic periapical lesion. The cases were followed for six months and one year and healing was evaluated quantitatively using cone beam computed tomography.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Authors: Carvalho CR, Reis RL, Oliveira JM Abstract A body of evidence indicates that peripheral nerves have an extraordinary yet limited capacity to regenerate after an injury. Peripheral nerve injuries have confounded professionals in this field, from neuroscientists to neurologists, plastic surgeons, and the scientific community. Despite all the efforts, full functional recovery is still seldom. The inadequate results attained with the "gold standard" autograft procedure still encourage a dynamic and energetic research around the world for establishing good performing tissue-engineered alternative graf...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Zhou Y, Xiao Y Abstract The clinical need for effective bone regeneration remains in huge demands. Although autologous and allogeneic bone grafts are generally considered "gold standard" treatments for bone defects, these approaches may result in various complications. Furthermore, safety considerations of gene- and cell-based therapies require further clarification and approval from regulatory authorities. Therefore, developing new therapeutic biomaterials that can empower endogenous regenerative properties to accelerate bone repair and regeneration is of great significance. Extracellular vesicl...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 27 June 2020Source: Arthroscopy TechniquesAuthor(s): Conner J. Paez, Brian J. Rebolledo
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Conclusions: This animal study has demonstrated the biocompatibility and normal healing features associated with the ReBOSSIS-85 bone graft (test material) when combined with autograft as an extender. ReBOSSIS-85 was more effective when a larger mass of test article was used in this study. Clinical Relevance: ReBOSSIS-85 can be used as an extender negating the need for large amounts of local or iliac crest bone in posterolateral fusions. PMID: 32577102 [PubMed - in process]
Source: Iowa orthopaedic journal - Category: Orthopaedics Tags: Iowa Orthop J Source Type: research
In this study, mandibular defects in six sheep were inoculated with 106 colony forming units of Staphylococcus aureus; three sheep were implanted with unloaded porous space maintainers and three sheep were implanted with vancomycin-loaded space maintainers within the defect site. During the same surgery, 3D-printed in vivo bioreactors containing autograft or xenograft were implanted adjacent to rib periosteum. After 9 weeks, animals were euthanized, and tissues were analyzed. Antibiotic-loaded space maintainers were able to prevent dehiscence of soft tissue overlying the space maintainer, reduce local inflammatory cells, e...
Source: Biomaterials - Category: Materials Science Authors: Tags: Biomaterials Source Type: research
(Texas A&M University) Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting. Researchers at Texas A&M University have now created superior bone grafts using primitive stem cells. They found that these cells help create very fertile scaffolds needed for bone to regenerate at the site of repair.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
This study aims to evaluate the role of staging arthroscopy in the diagnosis of knee chondral defects and subsequent surgical planning prior to autologous chondrocyte implantation (ACI), osteochondral allograft transplantation (OCA), and meniscus allograft transplantation (MAT). All patients who underwent staging arthroscopy prior to ACI, OCA, or MAT at our institution from 2005 to 2015 were identified. Medical records were reviewed to document the diagnosis and treatment plan based on symptoms, magnetic resonance imaging (MRI) findings and previous operative records. Operative records of the subsequent staging arthroscopy...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
CONCLUSION: The existence of a donor-recipient curvature disparity should be investigated as a possible underlying mechanism of refractory double AC. Total or subtotal full thickness recipient bed cut may be considered to repair donor-recipient curvature disparity in cases of DM rupture occurring during manual DALK. Repairing the DM rupture and avoiding a conversion to PK in high-risk transplant cases are crucial. PMID: 32525428 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
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