Bone regenerative medicine: metatarsus defects in sheep to evaluate new therapeutic strategies for human long bone defect. A systematic review

Large bone defects occur due to trauma, bone tumor resection, infections and metabolic, degenerative or congenital diseases 1. The larger the defect, the more difficult to treat it because the damage to repair exceeds the intrinsic capacity of regeneration, leading to non-union complications2. Nearly 2 million/year of bone grafts (autografts, allografts or xenografts) are performed worldwide3 and among them, autograft is the gold standard due to its osteoinductivity, osteogenicity and osteoconductivity1,4.

Source: Injury - May 10, 2020 Category: Orthopaedics Authors: Francesca Veronesi, Lucia Martini, Gianluca Giavaresi, Milena Fini Source Type: research