Pancreatic cancer stroma: an update on therapeutic targeting strategies

Nature Reviews Gastroenterology & Hepatology, Published online: 11 May 2020; doi:10.1038/s41575-020-0300-1The neoplastic epithelium of pancreatic cancer exists within a dense stroma that is recognized as a critical mediator of disease progression. This Review discusses our current understanding of the three principal constituents of pancreatic cancer stroma, their effect on the prevalent immune landscape and promising therapeutic targets within this compartment.
Source: Nature Reviews Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research