CD26 identifies a subpopulation of fibroblasts that produce the majority of collagen during wound healing in human skin

Fibroblasts produce collagens and other proteins that form the bulk of the extracellular matrix (ECM) in connective tissues. Emerging data point to functional heterogeneity of fibroblasts. However, the lack of sub-type specific markers hinders our understanding of the different roles of fibroblasts in ECM biology, wound healing, diseases and aging. We have investigated the utility of the cell surface protein CD26 (dipeptidyl peptidase-4) to identify functionally distinct fibroblast subpopulations in human skin.

Source: Journal of Investigative Dermatology - May 10, 2020 Category: Dermatology Authors: Christal A. Worthen, Yilei Cui, Jeffrey S. Orringer, Timothy M. Johnson, John J. Voorhees, Gary J. Fisher Tags: Original Article Source Type: research