Research Techniques Made Simple: Mouse Bacterial Skin Infection Models for Immunity Research

Bacterial skin infections are a major societal health burden and are increasingly difficult to treat due to the emergence of antibiotic resistant strains such as community-acquired methicillin-resistant Staphylococcus aureus. Understanding the immunological mechanisms that provide durable protection against skin infections has the potential to guide the development of immunotherapies and vaccines to engage the host immune response to combat these antibiotic resistant strains. To this end, mouse skin infection models allow researchers to examine host immunity by investigating the timing, inoculum, route of infection and the causative bacterial species in different wildtype mouse backgrounds as well as in knockout, transgenic and other types of genetically engineered mouse strains.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Research Techniques Made Simple Source Type: research