The American Brachytherapy society consensus statement for skin brachytherapy
Keratinocyte carcinoma (KC, previously nonmelanoma skin cancer) represents the most common cancer worldwide. While surgical treatment is commonly utilized, various radiation therapy techniques are available including external beam and brachytherapy. As such, the American Brachytherapy Society has created an updated consensus statement regarding the use of brachytherapy in the treatment of KCs.
Background Psoriasis is a chronic inflammatory skin disorder which may result in an increased cancer risk due to defects of immune surveillance. The relationship between psoriasis and risk of non-melanoma skin cancer (NMSC) has not yet been fully determined. The aim of this study was to update the evidence on the association between psoriasis and risk of NMSC.Methods We conducted an extensive literature search of publications in Pubmed, EMBASE, and Cochrane Library without restrictions on language from inception through August 2019 using predefined keywords. Eligible observational studies were selected if they assessed the...
Conclusion: Skin cancer prevalence and incidence is increasing worldwide. In our study, BCC was the most common type of skin cancer to be reported in our institute, which is similar to the majority of other international studies. PMID: 32601638 [PubMed - in process]
Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in humans. It is responsible for 20 % of all non-melanoma skin cancer (NMSC) cases globally and attributing to as high as 20 % of skin cancer deaths [1,2]. While the majority of the cSCC lesions are curable with surgical removal , around 5% metastasize, and for biologically more aggressive tumours, this rate could be as high as 37 % . The 5-year survival rate for cSCC patients with stage II disease (nodal disease) is 63 %, and for patients with stage III (metastatic) disease it is only 11 % .
Authors: Maraee A, Farag AGA, Gadallah MM, Abdou AG Abstract Non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represents 78.5% of all skin malignant tumours in Egypt. Dendritic cells can be found in almost all human tumours, they play an important role in antitumour immunity. The aim of the present study was to evaluate the percentage of Langerhans cells using CD1a in non-melanoma skin cancer, including BCC and SCC and to correlate this percentage with their clinicopathological features. The current study was performed on surgically excised specimens of 41 patients pr...
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer. All-trans retinoic acid (ATRA) has been previously proposed anti-tumor potential via inhibiting cancer cell growth by binding to the intracellular retinoic acid receptors (RAR). The ten-eleven translocation 2 (TET2) proteins oxidize the epigenetic mark 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and loss-functions of TET2 leading to hypermethylation have been established in various cancers. However, its role in cSCC remains unknown.
In this study, we measured HMGA2 expression in normal human keratinocytes and found a significant decrease in HMGA2 mRNA expression in adult keratinocytes compared to neonatal keratinocytes.
Nonmelanoma skin cancers (NMSCs) consist of two major subtypes, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Information about the NMSCs epidemiology limited, here we provide an estimate of the global burden of NMSCs. Based on the GBD study 2017, we analysed detailed data on NMSCs of incidence, mortality and the disability-adjusted life-years (DALYs) metric between 1990-2017. Estimated annual percentage changes (EAPCs) in NMSCs age standardized incidence, mortality and DALYs rate (ASIR, ASMR and ASDR), were calculated to quantify the temporal trends in ASR.
Risk factors for non-melanoma skin cancer (NMSC) include UVB exposure, genetic mutations, immunosuppression, and chronic inflammation. Activation of Toll-Like-Receptor 3 (TLR3), which recognizes dsRNA, leads to downstream activation of NF- κB and an upregulation of inflammatory cytokines. TLR3 protein expression is higher in moderately differentiated squamous cell carcinomas (SCCs) and infiltrative basal cell carcinomas (BCCs) compared to well-differentiated SCCs by immunohistochemistry (n> 6) suggesting TLR3 expression correlates with more aggressive NMSCs.
Melanoma and non-melanoma skin cancers (NMSCs) are two major forms of skin cancers. Melanoma is the most aggressive form of skin cancer related deaths while basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are most prevalent forms of NMSCs with over 5.3million yearly cases in the US. Due to huddles including resistance, bioavailability and adverse effects with available treatments, there is the need for effective strategies against skin cancer progression. The cyclin dependent kinase-2(CDK2), c-kit and mammalian target of rapamycin (mTOR), are attractive targets for new anticancer drug development.
Non-melanoma skin cancer is the most common form of cancer worldwide. We previously documented an anti-apoptotic role for CDC25A in cutaneous squamous cell carcinoma (SCC), an activity dependent on its association with 14-3-3 proteins. We hypothesized that targeting CDC25A-14-3-3 ε interactions may be an effective strategy for inducing skin cancer cell apoptosis. Co-immunoprecipitation revealed that CDC25A associated with 14-3-3ε, 14-3-3γ and 14-3-3ζ in SCC cells but not normal keratinocytes. Additionally, in SCC cells, overexpression of CDC25A induced Akt/BAD/Survivin p ro-survival signaling whi...