Pulmonary inflammation caused by silica dioxide nanoparticles in mice via TXNIP/NLRP3 signaling pathway

ConclusionCollectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1 β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research