Neurotoxicity of sub-anesthetic doses of sevoflurane and dexmedetomidine co-administration in neonatal rats.

CONCLUSIONS: In the neonatal rat model, co-administration of a clinically relevant dose of DEX (1 µg/kg) with a sub-anesthetic dose of SEVO (1.1%) does not affect the neurotoxicity of the anesthetic while co-administration of higher doses of DEX with SEVO 1.1% potentiates it. PMID: 32387222 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32387222?dopt=Abstract

Source: Neurotoxicology - May 4, 2020 Category: Neurology Authors: Perez-Zoghbi JF, Zhu W, Neudecker V, Grafe MR, Brambrink AM Tags: Neurotoxicology Source Type: research