Acetaminophen Oxidation And Inflammatory Markers - A Review From Hepatic Molecular Mechanisms And Preclinical Studies.
Acetaminophen Oxidation And Inflammatory Markers - A Review From Hepatic Molecular Mechanisms And Preclinical Studies.
Curr Drug Targets. 2020 May 09;:
Authors: Stefanello ST, de Carvalho NR, Reis SB, Soares FAA, Barcelos RP
Abstract
Acetaminophen is a widely used analgesic for pain management especially useful in chronic diseases, such as rheumatoid arthritis. However, easy access to this medicine has increased the occurrence of episodes of poisoning. Patients often develop severe liver damage, which may quickly lead to death. Consequently, numerous studies have been conducted to identify new biomarkers that allow the prediction of the degree of acetaminophen intoxication and thus intervene in a timely manner to save patients' lives. This review highlights the main mechanisms of the induction and progression of liver damage arising from acetaminophen poisoning. In addition, we have discussed the possibility of using new clinical biomarkers for detecting acetaminophen poisoning.
PMID: 32386489 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Stefanello ST, de Carvalho NR, Reis SB, Soares FAA, Barcelos RP Tags: Curr Drug Targets Source Type: research
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