Effects of rivaroxaban and dabigatran on local expression of coagulation and inflammatory factors within human aortic stenotic valves.

CONCLUSIONS: NOACs at therapeutic concentrations may inhibit the effects of FXa and thrombin at in vitro level. It might be speculated that long-term treatment with rivaroxaban or dabigatran could attenuate the progression of AS in humans.
PMID: 32387621 [PubMed - as supplied by publisher]

Source: Vascular Pharmacology - May 5, 2020 Category: Drugs & Pharmacology Authors: Wypasek E, Natorska J, Mazur P, Kopytek M, Gawęda B, Kapusta P, Madeja J, Iwaniec T, Kapelak B, Undas A Tags: Vascul Pharmacol Source Type: research