Atrial arrhythmogenesis in a rabbit model of chronic obstructive pulmonary disease

This study investigated the effects of COPD on AF triggers (pulmonary veins, PVs) and substrates (atria), and their potential underlying mechanisms. Electrocardiographic, echocardiographic, and biochemical studies were conducted in control rabbits and rabbits with human leukocyte elastase (0.3 unit/kg)-induced COPD. Conventional microelectrode, Western blotting, and histological examinations were performed on PV, left atrium (LA), right atrium, and sinoatrial node (SAN) preparations from control rabbits and those with COPD.

Source: Translational Research - May 9, 2020 Category: Research Authors: Chao-Shun Chan, You Shuei Lin, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Chun-Chun Hsu, Shih-Ann Chen, Yi-Jen Chen Source Type: research