Signaling properties of murine MPL and MPL mutants after stimulation with thrombopoietin and romiplostim

All our blood cells are produced from HSC in the bone marrow (BM). HSC have the potential to self-renew but also to differentiate into all mature blood cell lineages. These processes are guided by extracellular cues, including cytokines and their receptors. Among them, THPO and its receptor MPL control megakaryopoiesis, but also HSC maintenance, quiescence and post-transplant expansion [1 –3]. MPL was identified as the cellular homologue of the myeloproliferative leukemia virus oncogene v-Mpl [4, 5] and is a type one cytokine receptor similar to the erythropoietin (EPO) receptor.

Source: Experimental Hematology - May 9, 2020 Category: Hematology Authors: Marcel G E Rommel, Keven Hoerster, Christian Milde, Franziska Schenk, Luise Roser, Saskia Kohlscheen, Niels Heinz, Ute Modlich Source Type: research