Anesthetic management for cesarean delivery for a parturient with metaphyseal dysplasia and hypophosphatemic rickets

Hypophosphatemic rickets is a genetic condition, of estimated prevalence 1 per 20 000, that affects bone mineralization due to insufficient phosphate reabsorption. Decreased phosphate reabsorption, secondary to genetic mutations, leads to dysregulation of fibroblast growth factor 23. This can result in bone deformities, fractures, disproportionate short stature, and dental abscesses that may all prove severely debilitating into adulthood.1 Similar in presentation to rickets are the metaphyseal chondrodysplasias, a heterogenous group of disorders characterized by irregularities in the metaphysis of long bones and sparing of the epiphysial regions.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Tags: Correspondence Source Type: research