Retrospective Study of Intercalated Disk Defects Associated with Dilated Cardiomyopathy, Atrial Thrombosis, and Heart Failure in BALB/c Mice Deficient in IL4 Receptor α.

This report underscores the importance of carefully monitoring genetically modified mice colonies for unexpected phenotypes that may result from spontaneous or unintended mutations or enhanced strain background pathology.
PMID: 32384942 [PubMed - as supplied by publisher]

Source: Comparative Medicine - May 7, 2020 Category: Zoology Authors: Gozalo AS, Zerfas PM, Elkins WR, Gieseck Iii RL Tags: Comp Med Source Type: research