Adverse outcome pathways induced by 3,4-dimethylmethcathinone and 4-methylmethcathinone in differentiated human SH-SY5Y neuronal cells.

In conclusion, the mitochondrial impairment and oxidative stress observed for the tested cathinones may be key factors for their neurotoxicity, but different outcome pathways seem to be involved in the adverse effects, when compared to METH.
PMID: 32382956 [PubMed - as supplied by publisher]

Source: Archives of Toxicology - May 6, 2020 Category: Toxicology Authors: Soares J, Costa VM, Gaspar H, Santos S, Bastos ML, Carvalho F, Capela JP Tags: Arch Toxicol Source Type: research