Association of interleukin-17A gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multi-centre study.

CONCLUSION: The IL-17 rs2275913 A allele and A/A genotype were associated with high IL-17 serum levels and may contribute to susceptibility to JSLE and the development of LN in Egyptian children and adolescents. However, no significant association was evident between the studied IL-17A SNPs and other clinical phenotypes, disease activity scores or laboratory profile of JSLE.
PMID: 32380889 [PubMed - as supplied by publisher]

Source: Lupus - May 6, 2020 Category: Rheumatology Authors: Elkoumi MA, Allah MA, Mohamed FY, Boraey NF, Abdellatif SH, Shehab MM, Sherif AH, Akeel NE, Saleh RM, Elshreif AM, Abdelrahman HM, Soliman AA, Emam AA, Youssef MA, Fahmy DS, Sallam MM, Nawara AM, Elgohary EA, Ismael A, El-Kaffas SM, Sobeih AA, Ibrahim LM, Tags: Lupus Source Type: research