Neural Basis of Long-term Musical Memory in Cognitively Impaired Older Persons.

CONCLUSIONS: Long-known music activates a bilateral network of prefrontal, emotional, motor, auditory, and subcortical regions (cerebellum, putamen, limbic structures). This extensive activation, relative to recently-heard music, may offer structural and functional clues as to why long-term musical memory appears to be relatively preserved among cognitively impaired older persons. PMID: 32384286 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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n E Abstract Tau pathology and brain atrophy are the closest correlate of cognitive decline in Alzheimer's disease (AD). Understanding heterogeneity and longitudinal progression of atrophy during the disease course will play a key role in understanding AD pathogenesis. We propose a framework for longitudinal clustering that simultaneously: 1) incorporates whole brain data, 2) leverages unequal visits per individual, 3) compares clusters with a control group, 4) allows for study confounding effects, 5) provides cluster visualization, 6) measures clustering uncertainty. We used amyloid-β positive AD and negativ...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
In conclusion, our method can accurately predict scan type, and can quickly and automatically sort a brain MRI dataset virtually without the need for manual verification. In this way, our method can assist with properly organizing a dataset, which maximizes the shareability and integrity of the data.
Source: Neuroinformatics - Category: Neuroscience Source Type: research
CONCLUSION: Together, the clinical characteristics and the effect of the mutation would facilitate our understanding of PSEN1 in AD pathogenesis for the disease diagnosis and treatment. Future in vivo study is needed to evaluate the role of PSEN1 p.Ala285Val mutation in AD disease progression. PMID: 32589559 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
CONCLUSION: Moderate intensity exercise affects cortical and subcortical structures in preclinical AD patients. Thus, physical exercise has a potential to be an effective intervention to prevent future cognitive decline in those at high risk of AD. PMID: 32570297 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Authors: Marinescu RV, Lorenzi M, Blumberg SB, Young AL, Planell-Morell P, Oxtoby NP, Eshaghi A, Yong KX, Crutch SJ, Golland P, Alexander DC Abstract We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from larger multimodal datasets from common neurodegenerative diseases. DKT is a joint-disease generative model of biomarker progressions, which exploits bio...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
Conclusions: This work has shown that accurate amyloid PET images can be generated using trained CNNs with simultaneously-acquired MR images and PET images reconstructed from actual ultra-low-dose radiotracer injections. Acknowledgements: This work was made possible by the Michael J. Fox Foundation, the Stanford Alzheimer's Disease Research Center, the NIH Grant P41-EB015891, GE Healthcare, the Foundation of the ASNR, and Life Molecular Imaging.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Artificial Intelligence for Image Enhancement/Analysis and Disease Assessment Source Type: research
Conclusions: Training data suggests that eCBF measures from dynamic florbetapir-PET studies strongly correlate with tau positivity measured with flortaucipir-PET across all subjects irrespective of amyloid status. Successful development of this approach could simplify and decrease the cost of acquiring neuroimaging biomarkers of amyloid and tau. References: Raman F, et al. (2019) Biomarker Localization, Analysis, Visualization, Extraction, and Registration (BLAzER) Methodology for Research and Clinical Brain PET Applications. J Alzheimers Dis 70, 1241-1257. **NOTES: Data used in preparation of this article were obtained fr...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Amyloid & amp; Tau PET Source Type: research
Conclusion: The study demonstrates preliminary evidence of the potential beneficial impact of gamma-induction tACS protocols in AD, also showing the utility of Tau PET tracers as [18F]-AV-1451 for the reliable detection/quantification of modification in p-Tau deposition in AD. Acknowledgements: DARPA project D17AP00080, RO1A6060981, P41EB022544
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurodegenerative Diseases Source Type: research
The objective of this study was to investigate the brain metabolic pattern for normal aging using 18F-fluorodeoxyglucose (FDG) combined positron emission tomography and magnetic resonance imaging (PET/MRI). Methods: Resting-state brain FDG PET imaging was performed in a cohort of 200 gender-matched healthy subjects across a wide age range from 20 to 70 years old. All subjects had given their informed consent and were screened clinically to exclude organic brain disease. SVD-based PCA was used to identify the aging-related metabolic brain patterns for the subjects [2]. The expression scores of principal components (PCs) wer...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
1549Objectives: Molecular imaging of tauopathies is complicated by the differing specificities and off-target binding properties of available ligands for positron-emission-tomography (PET). [18F]-APN-1607 ([18F]-PM-PBB3) is a newly developed tau tracer. The aim of the study was to characterize the imaging properties of [18F]-APN-1607 in Alzheimer’s disease (AD) patients compared to normal control (NC) subjects. Methods: We obtained PET recordings with [18F]-APN-1607 and [18F]-FDG in patients with a clinical diagnosis of AD group (N=19, 61.83±11.89 y,7 male/12 female), along with an age-matched NC group ([18F]-...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
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