Centrosome abnormalities and polyploidy in murine mammary carcinomas with different degrees of hormone responsiveness.

Centrosome abnormalities and polyploidy in murine mammary carcinomas with different degrees of hormone responsiveness. Cancer Invest. 2020 May 07;:1-25 Authors: Bilinski M, Lanari C, Fabris VT Abstract Centrosome amplification leads to aberrant mitosis, giving rise to aneuploidy and it has been associated with poor prognosis in human cancers. The aim of this study was to evaluate the relationship between polyploidy, centrosome abnormalities and response to endocrine treatment in progestin-induced mouse mammary carcinomas. We found cells with three or more centrosomes in the polyploid tumors. The endocrine unresponsive tumors showed a higher average number of centrosomes per cell than the responsive tumors. The results suggest an association between polyploidy and centrosome amplification with the resistance to endocrine therapy in this luminal breast cancer model. PMID: 32378982 [PubMed - as supplied by publisher]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research