Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF ‐1/CXCR4 signalling pathway

ConclusionsIn mice with type ‐2 diabetes,LAV ‐BPIFB4 gene therapy promotes an advantageous remodelling of the heart, allowing it to better withstand diabetes ‐induced stress. These results support the viability of transferring healthy characteristics of longevity to attenuate diabetic cardiac disease.

Source: European Journal of Heart Failure - May 7, 2020 Category: Cardiology Authors: Zexu Dang, Elisa Avolio, Anita C. Thomas, Ashton Faulkner, Antonio P. Beltrami, Celeste Cervellin, Albino Carrizzo, Anna Maciag, Yue Gu, Elena Ciaglia, Nicoletta Finato, Antonio Damato, Gaia Spinetti, Aishah Alenzi, Stephen J. Paisey, Carmi Tags: Research Article Source Type: research