Study of Hypoxia-inducible factor-2 & #945; expression in the malignant transformation of Oral submucous fibrosis

Conclusion: Areca nut initiates fibrosis and subsequent hypoxia in OSF which triggers HIF-2α expression in the epithelium. HIF-2α could be a surrogate marker for cancer initiation and progression.

Source: Journal of Oral and Maxillofacial Pathology - May 7, 2020 Category: ENT & OMF Authors: Immanuel Joseph Joshua Elizabeth Umadevi K Rao Kannan Ranganathan Source Type: research