Critical role of bile acid (BA) in the cellular entry and permissiveness of Hepatitis B virus in vitro

ConclusionThis study demonstrates that enterohepatic humoral milieu such as BA, specifically tCDCA would directly regulate HBV DNA and its surface antigen expression in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. This is the first note to render HBV permissive to human or rodent hepatic and non-hepatic cells via sole manipulation of humoral milieu, thus establishing the platform for in vitro robust replication system of HBV.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research