Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle

This article will summarise the current state of knowledge linking mutations in presynaptic genes to ne urodevelopmental disorders by sequentially covering the various stages of the synaptic vesicle life cycle. It will also discuss how perturbations of specific stages within this recycling process could translate into human disease. Finally, it will also provide perspectives on the potential for futur e therapy that are targeted to presynaptic function.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: REVIEW Source Type: research