Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women.

Conclusions. This investigation provides the first evidence for sex-based differences in EPC activity and endothelial function in overweight middle-aged individuals; these differences are associated with alterations in NO production and may partly occur through downregulation of the GTPCH I pathway. The present results provide new insights into the mechanism underlying the preserved endothelial function in overweight premenopausal women and may uncover a potential therapeutic target for endothelial repair in overweight population. PMID: 32377428 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/32377428?dopt=Abstract

Source: Cardiology Research and Practice - May 8, 2020 Category: Cardiology Authors: Wu S, He H, Liu GX, Li XP, Yao S, Su HX, Li X, Ren Z, Zeng H, Liao J Tags: Cardiol Res Pract Source Type: research