Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays

ConclusionReduced osteoprotegerin, ACAN and HAPL1 are consistent with osteoclastic activation and high remodeling activity in BMLs. The pronounced increase in angiogenesis markers, hemoglobin and serum albumin support the presence of increased vascularity in subchondral bone affected by BMLs in OA. VEGFs and IL ‐6 are known nociceptive modulators, and increased levels are in keeping with pain being a clinical feature frequently associated with BMLs.

Source: International Journal of Rheumatic Diseases - May 6, 2020 Category: Rheumatology Authors: Maziar Shabestari, Yashar R. Shabestari, Maria A. Landin, Milaim Pepaj, Timothy P. Cleland, Janne E. Reseland, Erik F. Eriksen Tags: ORIGINAL ARTICLE Source Type: research