Airway Remodeling in Ferrets with Cigarette Smoke Induced COPD using µCT Imaging.

CONCLUSIONS: µCT-based airway measurements in ferrets are feasible and reproducible. Smoke exposed ferrets develop increased BWT and Pi4, changes similar to humans with chronic bronchitis. µCT can be used as a significant translational platform to measure dynamic airway morphological changes.
PMID: 32374671 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - May 5, 2020 Category: Cytology Authors: Stanford D, Kim H, Bodduluri S, LaFontaine J, Byzek SA, Schoeb TR, Harris ES, Nath HP, Bhatt SP, Raju SV, Rowe SM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research