Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression

Basal Cell Carcinoma (BCC) is the most common malignancy in Caucasian populations. Despite its low metastasis potential, the burden of the disease is important and is defined by the multiplicity of tumours in the field of UV exposure. Current targeted therapies have poor response rates in patients with advanced disease [1] and there are currently no accepted chemoprevention of BCCs justifying a better understanding of BCC molecular pathogenesis. BCC is caused by oncogenic activation of Hedgehog signaling, most commonly through inactivating mutations in the PTCH1 tumor suppressor gene [2].

Source: Journal of Dermatological Science - May 6, 2020 Category: Dermatology Authors: Rehan Villani, Seen Ling Sim, Edwige Roy, Brandon Wainwright, Mathias Francois, Kiarash Khosrotehrani Source Type: research