Paternal deficiency of complement component C1q leads to a preeclampsia-like pregnancy in wild-type female mice and vascular adaptations postpartum.

In conclusion, the ♀ C57BL/6J x ♂ C57BL/6J C1q-/- model recapitulates many aspects of the human preeclampsia syndrome in a low-risk, wild-type female mouse. The pregnancy-specific phenotype results in systemic maternal endothelial-dependent and -independent vascular dysfunction that persists postpartum.
PMID: 32374620 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - May 5, 2020 Category: Physiology Authors: Sutton EF, Gemmel M, Brands J, Gallaher MJ, Powers RW Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research