5-Fluorouracil Management of Oculofacial Scars: A Systematic Literature Review

Conclusions: High-quality randomized controlled trials are currently lacking, and the existing literature is predominately not specific to use of 5-FU on the face. These studies, however, suggest that intralesional 5-FU is safe and probably more effective than other options in the management of cutaneous scars in the oculofacial region. The delivery methods, timing, dosing, and concomitant therapies were highly variable. Further high-quality controlled studies specific to oculofacial scars may be indicated to assess the efficacy of 5-FU and to establish the best protocols for administering this medication.
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Major Reviews Source Type: research

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Authors: Vultaggio A, Nencini F, Bormioli S, Vivarelli E, Dies L, Rossi O, Parronchi P, Maggi E, Matucci A Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by multisystemic manifestations including asthma. Mepolizumab (300 mg/4 weeks) has recently been approved for EGPA. However, real-life data are scarce and report experiences with high doses of mepolizumab intravenously administered (750 mg/4 weeks). The aim of our study was to investigate in a real-life setting whether mepolizumab in EGPA patients at low doses would enable us 1) to control asthma symptoms, 2) to obtain ...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
This study aimed to determine the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma. METHODS: A retrospective cohort of patients with CS-dependent asthma aged 40 years or older was established using records from the Korean National Health Insurance Service database for 2005 to 2015. We classified the subjects into 2 groups according to the presence of COPD and evaluated the hazard ratio (HR) for all-cause mortality in patients with COPD relative to those without COPD. RESULTS: Of 8,021 patients with CS-dependent asthma, 3,121 (38.9%) had COPD. All-cause mortality was significantl...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
We report this consensus to support allergists and clinical immunologists to make optimal decisions under the urgent situation in Asia. PMID: 32638559 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
This article describes the current knowledge of inherited ocular disorders.
Source: Veterinary Clinics of North America: Equine Practice - Category: Veterinary Research Authors: Source Type: research
With remote work becoming a widespread option for Bay Area companies, it ’s important to have the tools and advice to build a home office that will serve you best to get your job done. While many employees adapt to remote work, companies are creating programs and methods to make it easier for their employees to function.  To protect your body and increase product ivity, it’s important to have a desk and chair that support your spine which will minimize neck and back pain. Since we spend so…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
CONCLUSION: Ocular foreign bodies represent a situation of non-negligable severity and thus require proper early management in order to prevent progression to visual loss or blindness. PMID: 32636035 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has caused 347,192 deaths around the world. The current evidence showed that severely ill patients tend to have a high concentration of pro-inflammatory cytokines, such as interleukin (IL)-6, compared to those who are moderately ill. The high level of cytokines also indicates a poor prognosis in COVID-19. Besides, excessive infiltration of pro-inflammatory cells, mainly involving macrophages and T-helper 17 cells, has been found in lung tissues of patients...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractObjectivesThe study aimed to compare the acetaminophen administration efficacy or its combination with codeine for pain control in acute apical abscesses cases.Materials and MethodsThirty-nine patients who sought emergency treatment in the Faculty of Dentistry of the Federal University of Rio Grande do Sul were included, all of them with acute apical abscess diagnosis. These patients were divided into two groups: acetaminophen group —prescription of acetaminophen (1000 mg) and acetaminophen–codeine group—prescription of acetaminophen (1000 mg) + codeine (30 mg), both w...
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
Publication date: Available online 8 July 2020Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Shakti Goel, Vicky Varghese, Tyfik Demir
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Publication date: Available online 9 July 2020Source: Medical Journal Armed Forces IndiaAuthor(s): Vineet Kumar Dhyani, Sanjay Chhabra, Vinay Kumar Sharma, Abha Dhyani
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
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