Upregulation of miR-496 rescues propofol-induced neurotoxicity by targeting Rho Associated Coiled-Coil Containing Protein Kinase 2 (ROCK2) in prefrontal cortical neurons.

CONCLUSION: miR-496 was decreased in PFC neurons treated with propofol, and overexpression of miR-496 attenuated propofol-induced neurotoxicity by targeting ROCK2. miR-496 and ROCK2 may be promising targets for protecting propofol-induced neurotoxicity. PMID: 32370715 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32370715?dopt=Abstract

Source: Current Neurovascular Research - May 4, 2020 Category: Neurology Authors: Mao Z, Wang W, Gong H, Wu Y, Zhang Y, Wang X Tags: Curr Neurovasc Res Source Type: research