Does a compromised placenta contribute to transgenerational transmission of metabolic dysfunction in polycystic ovary syndrome?

Polycystic ovary syndrome (PCOS) comprises at least two of the following: hyperandrogenism, intermittent or absent menstrual cycles, and polycystic ovaries. It affects 15% −20% of women in their reproductive years, compromising their fertility, fecundity, and cardiometabolic health (1). Assisted reproduction is a common prerequisite for a high conception rate in women with PCOS; but regardless of method of conception, pregnant women are at increased risk for pregnan cy-induced hypertension, preeclampsia, gestational diabetes, spontaneous preterm labor, need for cesarean delivery, and thus severe maternal morbidity.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research