Genetic analysis of pharmacogenomic VIP variants of ABCB1, VDR and TPMT genes in an ethnically isolated population from the North Caucasus living in Jordan.

CONCLUSION: Significant differences in allelic frequencies of eleven ABCB1, VDR and TPMT VIP variants were found between Jordanian Chechens and other populations. In our study, the most populations that are similar to Chechens are those from South Asian, European (Finnish) and European, including: Utah residents with Northern and Western European ancestry, Toscani in Italia, Mexican ancestry in Los Angeles and Circassian from Jordan. The level of similarity between Chechens and those populations means that they might have shared high levels of gene flow in the past. The results obtained in this study will contribute to the worldwide pharmacogenomic databases and provide valuable information for future studies and better individualized treatments.
PMID: 32368972 [PubMed - as supplied by publisher]

Source: Current Drug Metabolism - May 3, 2020 Category: Drugs & Pharmacology Authors: Al-Eitan LN, Al-Maqableh HW, Mohammad NN, Hakooz NM, Dajani RB Tags: Curr Drug Metab Source Type: research