Prediction of trimethoprim/sulfamethoxazole resistance in community-onset urinary tract infections
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Madeline DeMarsh, P. Brandon Bookstaver, Caroline Gordon, Juanne Lim, Nicole Griffith, Nicole K. Bookstaver, Julie Ann Justo, Joseph Kohn, Majdi N. Al-Hasan, the Prisma Health Antimicrobial Stewardship Support Team (PHASST)
Reducing the need for antibiotics is crucial in addressing the global threat of antimicrobial resistance. Catheter-associated urinary tract infection (CAUTI) is one of the most frequent device-related infectio...
Publication date: Available online 30 June 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Juan Xu, Wenping Lin, Yanmin Chen, Fang He
We examined whether reflexing to urine culture only if a urinalysis (UA) found greater than 10 WBC/hpf decreased urine culturing.ResultsIn acute-care, reflex culturing resulted in a 39% time series regression analysis adjusted decrease in the rate of cultures performed (pre-intervention, 3.6 cultures/100 days vs. Post-intervention, 1.8 cultures/100 days,p
ConclusionStandard treatment guidelines did not consider local AMR recommendations for empirically prescribing antibacterials for common infectious syndromes. The AMR reviews published in the country produced poor methodologic quality evidence for clinical applications. This highlights the need to improve the methodologic quality to provide the best available evidence for clinical decision-making and curb the ongoing AMR in Ethiopia.Trial registrationRetrospectively registered (15/07/2020).
Publication date: September 2020Source: Journal of Global Antimicrobial Resistance, Volume 22Author(s): Nahid Karami, Anna Lindblom, Shora Yazdanshenas, Viktoria Lindén, Christina Åhrén
The objective of this review is to provide an overview of how basic science discoveries are elucidating essential innate host defenses in the kidney and urinary tract. In doing so, we highlight how these findings may ultimately translate into the clinic as new biomarkers or therapies for urinary tract infection.
in Khurshid Staphylococcus saprophyticus is a uropathogenic bacteria responsible for acute urinary tract infections (UTIs) mainly in young female patients. Patients suffering from urinary catheterization, pregnant patients, the elderly as well as those with nosocomial UTIs are at greater risk of the colonizing S. saprophyticus infection. The causative factors include benign prostatic hyperplasia, indwelling catheter, neurogenic bladder, pregnancy, and history of frequent UTIs. Recent findings have exhibited that S. saprophyticus is resistant to several antimicrobial agents. Moreover, there is a global concern regarding...
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Fatemeh Mottaghizadeh, Hanieh Mohajjel Shoja, Mehri Haeili, Davood Darban-Sarokhalil
Conclusions: Among the most common pathogens isolated from hospitalized patients with cUTI, the rates of single resistance to common treatments and of cross-resistance to these regimens are substantial. Knowing the patterns of cross-resistance may help clinicians tailor empiric therapy more precisely. PMID: 32423953 [PubMed - as supplied by publisher]
In conclusion, the most interesting finding is the association of iss with septic shock. Adhesins are important for UTI pathogenesis, while otherwise low-pathogenic isolates from the microbiota can cause post-prostate biopsy sepsis. PMID: 32423949 [PubMed - as supplied by publisher]