Programmed death-ligand 1 expression profiling in thymic epithelial cell tumors: Clinicopathological features and quantitative digital image analyses

Thymic epithelial cell tumors (TETs) form a group of rare neoplasms arising in the anterior mediastinum [1]. The histological subtypes according to the World Health Organization (WHO) classification vary from the low-grade type A thymomas to the high-grade type B3 thymomas and thymic carcinomas (TCs) [2]. Therapy with immune checkpoint inhibitors has recently been approved for non-small cell lung cancer (NSCLC) and has shown promising results, with clinical efficacy predictable on the basis of the extent of programmed death-ligand 1 (PD-L1) expression as determined by immunohistochemistry [3].

Source: Lung Cancer - May 4, 2020 Category: Cancer & Oncology Authors: Shunta Ishihara, Satoru Okada, Hiroshi Ogi, Yoshinori Kodama, Masanori Shimomura, Hiroaki Tsunezuka, Kyoko Itoh, Alexander Marx, Masayoshi Inoue Source Type: research