Pencil beam scanning proton therapy for the treatment of craniopharyngioma complicated with radiation-induced cerebral vasculopathies: a dosimetric and linear energy transfer (LET) evaluation

Radiation-induced cerebral vasculopathy (RICV) has been described in paediatric patients after radiation therapy (RT) for tumours of optic tracts, hypothalamus, and suprasellar region [1,2]. Delayed RICV mainly results from an accelerated arteriosclerosis process of small and medium sized vessels within the radiation field [3,4]. This complication can present as moyamoya syndrome, which results from stenosis or occlusion of large and intermediate cerebral arteries [5]. The real incidence of RT-induced stenosis of carotid arteries and intracerebral arteries is however not well established.

Source: Radiotherapy and Oncology - May 4, 2020 Category: Radiology Authors: Alessandra Bolsi, Lorenzo Placidi, Alessia Pica, Frank Ahllhelm, Marc Walser, Tony Lomax, Damien C. Weber Tags: Original Article Source Type: research